affron® is a new generation extract obtained from saffron stigmas (Crocus sativus L.).
One of the main causes of depression is the reduction of some neurotransmitters related to mood (carr et al., 2011), mostly serotonin, norepinephrine and dopamine.
Most of the antidepressants currently used are selective inhibitors of the reuptake of these neurotransmitters (Serretti et al., 2007), but these drugs have side effects associated.
Previous scientific studies have shown that saffron is effective against depression and related disorders.1-4
Safranal and crocins are responsible for the increase of neurotransmitters in the brain.7-9
First clinical trial performed with a commercial saffron extract for
A randomized double-blind placebo and parallel controlled Gold Standard clinical trial was performed with 128 participants during 4 weeks to determine the efficacy of affron® on mood.
The clinical study was reviewed and approved by the Ethic Committee of Clinical Research of Queensland, collected by the “Australian New Zealand Clinical Trials Registry” (approval number HREC2014002), following the current legislation (National Health and Medical Research Council in Australia).
Natural alternative for the prevention of mood disorders related to depresion
Diminishes tension, stress, anxiety, depression, anger and tiredness
Increases vigor and positive mood
Improves sleep quality
affron® is aunique natural Saffron extract concentrated in Lepticrosalides®.
Lepticrosalides®10 are the main bioactive componets related to the prevention of depression disorders, and also responsible for organoleptic properties of Saffron.
Lepticrosalides are analyzed by High Performance Liquid Chromatography (HPLC) which is an objetive analytical technique to determine these bioactive compounds in affron® Lepticrosalides®.
Lepticrosalides® by HPLC: most accurate, isomers differentiation, objetive method, detection of possible fraud or plant foreing matter.
In a placebo-controlled trial in 40 patients suffering from depression, Saffron was found to be significantly superior over placebo.1
In a clinical double-blind study, 30 patients with mild to moderate depression were either treated with Saffron (stigma’s extract) or with 100 mg imipramin for 6 weeks: the effects were found to be equivalent, with a better tolerability of Safron.2
In a six week randomized, double-blind pilot trial, efficacy of saffron extract was compared with 20 mg of fluoxetin in 40 patients whit mild to moderate depression: Saffron at this dose was found to be effective similar to fluoxetine.3
In a double-blind, randomised and placebo-controlled trial, 47 women aged 20-45 years with diagnosed PMS (Pre-menstrual syndrome) recived saffron or placebo for two menstrual cycles: Saffron was clinically effective in relieving symptoms of PMS, including mood (anxiety, irritability, depression, nervous tension, mood swings and out of control).4
1. Akhondzadeh S, et al., (2005) Phytotherapy
2. Akhondzadeh S, et al., (2004) BMC Complementary
and Alternative Medicine.
3. Noorbala, A. A., et al., (2005) Journal of
4. Agha-Hosseini M, et al., (2008)
5. Carr et al., (2011). Psycopharmacology, 213.