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AFFRON®EYE and its benefits

AFFRON®EYE is Innovation for the vision. Obtained from spanish quality saffron stigmas (Crocus Sativus L.) AFFRON®EYE has a natural content in Crocins, the major carotenoids in saffron, with high antioxidant capacity, which protect against blue ligth, improve blood circulation in the retina1 and prevent from macular degeneration (AMD-Aged
macular degeneration).

The efficacy of Luteine

in vivo” study on going preliminary show AFFRON®EYE may improve Luteine in AMD cases.

Eye health and visual performance can be affected by oxidative stress caused by free radicals, light exposure, etc. Oxidactive stress affects overall eye health and may increase the risk of diseases such as AMD (Aged-Related Macular Degeneration) over time, which implies a rapid decline in quality of life.

AFFRON®EYE from saffron stigmas is a natural alternative solution that protects from retinal oxidative stress due to its antioxidant properties.2

AFFRON®EYE benefits

Limits the free radicals reaction 1-4

Increases blood flow in retina and choroid 1

Improves oxygen diffusivity in the eye 2

Protects againt blue light 4

AFFRON®EYE the way it works

AFFRON®EYE exerts eye protection and prevents from AMD or related diseases. The concentration of natural crocins (Figure 1) in AFFRON®EYE, which confer red color to saffron stigmas, are also responsible for the antioxidant capacity against oxidative stress in the eye.

Crocins and the corresponding aglycon crocetin (Figure 1), helps photoreceptors recovering from retinal damage, helping prevent the development of AMD.3-6

The antioxidan characteristics of crocin and crocetin protect retina against oxidative damage caused by light exposure, free radicals and daily oxidative stress that are related to eye diseases.

Figure 1. Biosyntesis pathway of saffron carotenoids

AFFRON®EYE absorption and metabolism

  • Crocin is hidrolyzed to crocetin in the stomach (Figure 2).
  • Crocetin is metabolized in the intestine.

  • Crocin is absorbed as crocetin gluconoride conjugates.
  • Finally are rapidly incorporate into the blood circulation rearching target tissues such as retina.

Scientific Evidences

  • In a 3 months placebo-controlled, double-blind crossover study, 25 patients with early Age-Related Macular Degeneration (AMD) received saffron or placebo. Treatment showed that shortterm saffron supplementation improves retinal flicker sensitivity in early AMD.3
  • A study administrated rats either β-carotene or saffron for 6 weeks. Saffron was effective in protecting photoreceptors from retinal stress, maintaining both morphology and function.4
  • The data reported by Natoli et al., (2010) provides insight into how Saffron acts against lilght damage showing the protective effect of saffron in eye photoreceptors.5
  • The investigation of crocin effect against ligh-induced photoreceptor death in an in vitro model provides experimental evidence of the ability of this saffron component to suppres light stress and to block photoreceptors cell death, showing antioxidant properties and preventing lipid peroxidation.6

Scientific References

1. Xuan et al., (1999). Journal of ocular pharmacology
and therapeutics 15.
2. Bisti et al., (2014). Visual Neuroscience 31.
3. Benedetto Falsini et al., (2010)
Investigative  Ophothalmology & Visual
Science 51 (12).

4. Rita Maccarone et al., (2008). Investigative Ophthalmology
& Visual Science 49 (3).
5. Ricardo Natoli et al., (2010). Molecular Vision 16.
6. Aicha Laabich et al., (2006). Investigative Ophthalmology
& Visual Science 47 (7).







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