Strengthens the Immune System


olivactive® and its benefits

olivactive®   is an olive leaves extract, natural source of Oleuropein, standardized by HPLC.

Recognized as:

  • Boosts Immune System.
  • Stimulates phagotytosis.
  • Against microbial agents.
  • Strong antioxidant capacity.
  • With specific bioflavonoids which limit the
    realease of sugar into the blood.


oliveactive® is recommended to strengthen the immune system and relieve fatige in case if infection (Lee-Huang, et al., 2003). Olivactive increases teh physiological resistance of the organism in case of severe environmental conditions due to the presence of Oleuropein (Figure1).



oliveactive® the way it works

Patients with abnormal antioxidant status or high oxidative stress in special cases such as diabetes, leads to tissue damage, with lipid peroxidation, inactivation of proteins, and protein glycation as intermediate mechanisms for complications including retinopathy, nephropathy, and coronary heart disease.

The higher oxidative stress may affect the Immune System, and therefore increases the amount of infections in patients with Diabetes Mellitus. Some microorganisms become more virulent in a high glucose environment, also an increased adherence of microorganisms to diabetic compared to nondiabetic cells occurs.

It has been postulated that supplementation with dietary antioxidant compounds may offer some protection against these complications through their roles as inhibitors of glycation and as free radical scavengers. Recent interests were also in the use of non-vitamin antioxidants such as flavonoids and polyphenols in reducing the negative effect of oxidative stress and free radicals in diabetic patients.

Studies have shown that oleuropein possesses a wide range of pharmacologic and health promoting properties, chiefly immune-stimulant. In fact, oleuropein has antioxidant and anti-in-flammatory activities that strengthen the immune system and relieves chronic fatigue because of the phagocytosis stimulation performed by Oleuropein.


Oleuropein and inmune system:

Scientific Evidences

The olive leaves have been used for thousands of years as a natural remedy for the treatment of different diseases in the mediterranean culture (Agalias et al., 2005), and in the recent years, the scientific community has shown a great interes because of the health benefits the publication of several scientific studies:

  1. Walker et al., (1997) published the antibiotic properties of Oleuropein against 126 pathogen microorganisms, most of them notoriously antibiotic-resistant. Oleuropein seems to be more effective than other natural antibiotic, both in wide spectrum capabilities and in potency.
  2. Markin et al., (2003) showed antimicrobial activity of Oleuropein against fungi and some bacteria. In fact, Oleuropein is effective when prolonged use of antobiotics, encouraging development of opportunistic infections and weakened immune system.6
  3. Recently, AIDS patients have begun to use OLE for a variety of indications, among them to strengthen the immune system, to relieve chronic fatigue, to boost the effects of anti-HIV medications, and to treat HIV-associated Kaposi’s sarcoma and HSV infections (referencia).
    Oleuropein exerts a direct stimula tion of phagocytosis (Fig. 1) as a response of the immune system to microbes of all types.7


oliveactive®  bioflavonoids: glycemic response effects

Luteolin and Luteolin-7-o-glucoside can achieve 100% of inhibitory activity of α-glucosidase and α-amilase at certain concentration (Michelle de Sales et al., 2002; Kim et al., 2014; Ito & Takeda, 2013).

Scientifyc References

1. Walker (1997). M. Kesington Publishing Corp.
2. Soler-Rivas, C. et al., (2000) J Sci
Food Agric 80, 1013-1023.
3. Lee-Huang, S., et al., (2003) BiochemBiophys
Res Commun, 307, 1029-1037.
4. Fitó, M. et al., (2007) Ann Ist Super Sanita,
43, 375-81.

5. Marki et al., (2003) Mycoses 46.
6. Visioli, F. et al., (1998) Life Sci. 62,
7. Agalias, A. et al., (2005) J- Liq. Chorm. Rel.
Tech.28, 1557-1571.


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