Olive Leaf-Based Support Helps Ease Winter Chills

Ward off winter cold and flu symptoms with two olive leaf centered formulations

This winter, Pharmactive Biotech Products, S.L. introduces two botanical formulations based on Mediterranean’ traditional medicine. Isenolic® branded olive leaf (Olea europaea) extract is locally sourced from olive trees grown in Mediterranean fields and is extracted under a fully controlled process that ensures the highest purity and potency. Isenolic COMPLEX® enhances the original formula with extract from leaves of the ribwort plantain (Plantago lanceolata). The plants are supplied by trusted farmers in Europe.

According to new market data from Innova Market Insights, 54% of global consumers say that, due to COVID-19, they have spent time educating themselves on ingredients and procedures that can boost their immune health.
The plant world provides a bounty of natural solutions studied for possessing chemical compounds believed to help naturally support the immune system and help weather the cold and flu onslaught more swiftly and effectively. We nurture and extract a powerful all-natural immune and respiratory aid sourced from the olive tree ardently formulated into two Pharmactive branded products.

“Our formulas have undergone rigorous clinical inquiry, bringing our products to the forefront of science,” states Alberto Espinel, Manager of Strategic R&D in Active and Functional Natural Ingredients for Pharmactive.

Olive leaf first gained recognition as a compelling culinary and medicinal in the Bible “The fruit will be for food and the leaf for medicine” (Ezekiel 47:12). According to anecdotal data It was historically regarded to be a popular remedy for reducing fever and commonly used to treat inflammation, common cold, influenza, shingles and lower intestinal disorders.

Over the last century olive leaf has been put under extensive scientific inquiry exploring the botanical’s antioxidant, antibacterial, antimicrobial, anti-inflammatory, and immune-stimulating properties. These activities have been attributed to oleuropein, a prime bioactive component in olive leaf.

Pharmactive’s Isenolic branded olive leaf extract is is standardized to ≥4% elenolic acid by HPLC. Elenolic acid is a derivative of oleuropein studied for it potential to help protect against viral seasonal infections and promote immune health. This bioactive compound contributes to the antimicrobial and antiviral functions of olive leaves, and has been shown in studies dating back decades to specifically target influenza A and B types, as well as para-influenza 1,2,3. It directly penetrates the cells thus blocking the entry of specific viruses.

The studies also focused on the compound’s capabilities in preventing and reducing symptoms of viral and microbial infections, including shortening the duration of colds. A Pharmactive in vitro study demonstrated Isenolic’s potent inhibition effect on neuraminidase activity. Neuraminidase is a key enzyme present in the flu virus that acts to disassemble the virus from the host-cell membrane, promoting its liberation to infect new cells.

Pharmactive’s second formulation, Isenolic® COMPLEX, is composed of its branded Isenolic olive leaf extract boosted with ribwort plantain (Plantago lanceolata). The combination has proven supportive in mitigating throat irritations and coughs as well as curbing viral proliferation.

Plantain is a wild-grown, nutritious leafy vegetable that carries a long tradition of safe use for helping to ease lung congestion and dry irritated coughs. It is traditionally consumed as a hot beverage or broth. In addition to the natural helpful compounds, the leaves also contain gums that provide a soothing cough-suppressant, and an anti-inflammatory effect on the lower respiratory tract. It also has been attributed tissue healing properties.

Ribwort plantain’s unique composition of phenylethanoids and bioavailable verbascosides has exhibited multifaceted beneficial capabilities, including anti-inflammatory, antimicrobial, tissue-healing, and antibacterial activity against a variety of gram-positive and gram-negative pathogenic bacterial strains, including Streptococcus pneumonia.

The union of two classic botanicals in one synergistic formula provides an all-encompassing solution for actively addressing common cold and flu symptoms. Moreover, being highly water-soluble Isenolic Complex can be readily integrated into a range palate-pleasing applications, including foods, beverages, and chewables.

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Pharmactive Biotech Products, S.L. is a privately-owned Spanish company that develops, and manufactures differentiated natural ingredients supported by scientific evidence. Pharmactive makes these innovative ingredients available to other companies in the Nutraceutical, Pharmaceutical and Veterinary Industries for marketing/distribution.


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